الفهرس 
Title : A pharmaceutical study on colontargeted delivery systems of an anti-inflammatory drug
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Abstract
Colon-targeted drug delivery has been the focus of numerous studies due to its potential to improve treatment of local diseases affecting the colon, while minimizing systemic drug side effects. Some examples of the diseases which impact the colon include Crohn{u2019}s disease (CD) and ulcerative colitis (UC). In literature, different strategies have been used to target the inflamed colon after oral drug administration. Strategies for specific colon drug delivery include the utilization of pro-drugs, exploitation of higher colonic pH values, and enzymatic activity of colonic micro flora, intestinal transit time and colonic pressure. In general, dimensions of the delivery system greatly influence the targeting of the inflamed colon. Size-dependency of particles has a considerable impact on their epithelial uptake. A favoured accumulation in the inflamed colon tissues has been found for particles having sizes in the nanometer-range. It has been shown in experimental colitis models that nanosized particles are more readily up taken by cells that are immune related such as macrophages or dendritic cells in the site of active inflammation.The nano spray drying is one of the advanced technologies to produce nanoparticles.The nano spray dryer can produce relatively high yield of nanosized particles which possess narrow particle size distributions.Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for the treatment of colonic inflammatory conditions.The main disadvantage for the use of classic NSAIDS is the development of gastrointestinal toxicity including mucosal injury in the form of erosions and ulcers accompanied by upper gastrointestinal (GI), small bowel or colonic bleeding and rarely perforation and obstruction due to stricture formation