الفهرس 
Introduction and RationaleOnly 14 pages are availabe for public view
 |  | from | 142 |  |  |
| | | from | 142 | | |
Abstract
One of the autoimmune diseases that damage the joint and synovial tissues is Rheumatoid arthritis (RA). It reveals the effects of 1% of the world population and 0.3% of Egyptians. It is considered a disabling, chronic, inflammatory condition that can cause long-term impairment. It is more predominant in women. Early detection and management are necessary to avoid permanent injury and impairment of vital bodily functions. There is a need for medications that cause biological reaction modifications, and target parts of the immune system that trigger inflammation. RA is characterized by joint infiltration by T cells, B cells, macrophages and neutrophils, and increased synthesis of proinflammatory cytokines and chemokines.
The chemokine C-C motif ligand 4 (CCL4) also known as Macrophage Inflammatory Proteins -1β (MIP- 1β) is one of the major forms of chemotactic cytokines. In humans, MIP proteins orchestrate acute and chronic inflammatory responses by recruiting pro-inflammatory