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Abstract Aim: The aim of this study is to determine the accuracy of serology in the diagnosis of temporomandibular joint arthritis.Methodology: We studied 20 patients suffering from temporomandibular joint arthritis and each patient went through two tests index test, serology (including ANA, Rheumatoid factor, C-reactive protein, Anti-Cyclic Citrullinated Peptide and HLA-B27) And reference test, arthroscopic guided synovial membrane biopsy of TMJ Result: all the patients showed negative results regarding the index test while the reference test showed Evident degeneration and damaged fibrocartilage and synovium Conclusion: use of serology markers is not an accurate method for diagnosis of TMJ arthritis while the best way is arthroscopic guided synovial membrane biopsy of the TMJ |