الفهرس 
Title: Evaluation of Cubilin Gene Variants in Egyptian Children with Systemic Lupus Erythematosus
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Abstract
Background: Juvnile Systemic lupus erythematous (jSLE) is an autoimmune, multisystem disease with poor outcomes in lupus nephritis. Proteinuria is the main characteristic of LN. Cubilin is a protein responsible for albumin reabsorption in proximal tubules. Variants in CUBN (rs1801222&rs1801239) have been associated with albuminuria in diabetic nephropathy. Our main objective is to study the relationship between cubilin gene variants and nephritis in SLE patients.Patient and Methods:This is a cross-sectional, analytical study conducted on 154 children, 77 JSLE patients and 77 apparently healthy control. Patients were recruited from Pediatric Rheumatology clinic, Cairo University. All study subjects were subjected to full history taking, clinical manifestations of SLE, assessment of disease activity and damage index and laboratory investigation .CUBN variants (rs1801222,rs1801239) were detected by Taqman Real Time PCR.Results: Mean age of patients was (11.9 ± 2.30) with mean disease duration 2.31 years, with male: famle ratio 1:4.9. Lupus nephiritis was found in 75% of patients.There was a statistically significant relation between CUBN variants(rs1801222 and rs1801239) and family history of SLE, P-value (0.04) and (0.014) respectively.No statistically significant difference was found between CUBN variants and different disease manifestation including nephritis