الفهرس 
Title: Preparation and Biophysical characterization of Different Iron Oxide Nanoparticles Formulations
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Abstract
The iron oxide nanoparticles (IONPs) have huge applications in biomedicine. The change in properties of IONPs like surface charge and agglomeration has a noticeable impact on their effect. In this study, an assessment of the physico-chemical features of various green synthesized IONPs compared with their chemically synthesized ones has been carried out. IONPs were prepared chemically (Chem-IONPs) and through green ways using curcumin (Cur-IONPs), aloe Vera (AV-IONPs), and green tea (GT-IONPs) extracts. All synthesized IONPs were characterized using transmission electron microscopy (TEM), zeta potential measurements, UV{u2013}Vis spectroscopy, X-ray diffraction (XRD), vibrating sample magnetometer (VSM), differential scanning calorimetry (DSC), and Fourier-transform infrared (FTIR) techniques. Moreover, the DPPH scavenging activity of the prepared nanoparticles was tested. TEM results revealed that Chem-IONPs have a square shape while the green synthesized IONPs have semi-spherical shapes. Spectrophotometry measurements showed that all IONPs have peaks in the UV wavelength range. Zeta potential investigation indicated that GT-IONPs were the most stable with an average zeta potential of -41.4 mV. XRD indicated that GT-IONPs have the highest crystalline structure. Thermal stability tested by DSC showed that Chem-IONPs was the least thermal stable sample whereas AV-IONPs were the most stable one with a transition temperature of 398oC.VSM results revealed that IONPs prepared using curcumin have the highest super-paramagnetic properties. FTIR results showed slight changes in the characteristic peaks of IONPs, these changes are due to the structural change in the nanoparticles due to curcumin, green tea and aloe vera encapsulation. The antioxidant activity of Cur-IONPs was the highest in the DPPH test. The present study showed, in a comparative way, the effect of different routes of IONPs synthesis on their physicochemical properties.These diverse properties may have great usage in various biomedical applications