الفهرس 
Association of polymorphism in survivin gene and the risk of hepatocellular carcinoma among hepatitis C virus Egyptian patients
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Abstract
Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver. Liver cirrhosis increases the risk of developing HCC by 80% to 90%. Hepatitis C virus (HCV), which is highly prevalent in Egypt, is the second most common risk factor for HCC. The product of the Survivin gene is one of the strongest inhibitors of apoptosis as it plays an important role in the development of HCC and its overexpression is associated with increased risk of cancer.This study aims to investigate the relation between Survivin gene polymorphisms and the risk of HCC among Egyptian population with HCV.The study was conducted on 164 participants, of whom 57 were cirrhotic patients, 57 were HCC patients and 50 were healthy controls. Liver enzymes and serum bilirubin, albumin, and Ü fetoprotein were determined. In addition, Survivin polymorphism, including two locus of rs1042489 and rs 8073069, were selected and genotyped by TaqMan® MGB probes for the detection of single nucleotide polymorphisms (SNPs).The results showed that for rs 1042489, only 32 participants (19.5%) were TT homozygous wild genotype, whereas, the other 132 (80.5%) were either CC or CT genotypes. In addition, for the rs 8073069, only 2 (1.2%) participants were GG homozygous wild genotype, whereas, the other 162 (98.2%) were either CC or GC.Regarding rs1042489, there was a significant difference observed between HCC patients and the healthy controls in both of TC and CC genotypes (Odds ratio=15.5, 95% CI: 3.299-72.825, P<0.001), (Odds ratio=44, 95% CI: 8.025-241.254, P<0.001), respectively