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Abstract Aim: The aim of this study was to compare the effect of MEBO versus 0.2% hyaluronic acid gel (Gengigel) applied to palatal donor site on post-operative pain reduction and wound healing after free gingival graft harvesting. Methodology :Thirty nine patients with different mucogingival defects were included in this study for harvesting a free gingival graft for soft tissue augmentation. Patients were randomly assigned into three equal groups; group I where MEBO was applied to the donor site and covered with periodontal pack, group II where 0.2% hyaluronic acid gel was applied to the donor site and covered with periodontal pack and group III where the palatal wound was covered by periodontal pack only. Postoperative pain following harvesting FGG was recorded using the Visual Analogue Scale Score (1-10) for a period of 7 days.Analgesic consumption was recorded for 7 days postoperatively. Wound size was measured at baseline, day 3, day 7, day 14, and day 21. Postoperative healing of the palatal wound was assessed by Visual Analogue Scale score for color match at day 3, day 7, day 14, day 21 and 42 days. Results: Results of this study showed significant postoperative pain reduction for the three groups, MEBO showed statistically significant less VAS score compared to both groups at day 2 (p=0.006) and day 3 (p=0.008) while HA showed statistically significant less VAS score compared to control group at day 3 (p=0.008). Both MEBO and HA showed statistically significant less total analgesic consumption (p=0.002) |