الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 69 |  |  |
| | | from | 69 | | |
Abstract
DM is a collection of disorders marked by long-lasting high glucose level caused by insulin injection, insulin act, or together.
IR is a sign of T2DM, which is caused by insulin easiness, diminishing insulin output, and eventually pancreatic beta-cell disaster.
DM problems are normal in cases with either T1 or T2 DM, but they can cause substantial morbidity and mortality. Microvascular and macrovascular problems of DM are the most common, with the previous consuming a meaningfully higher prevalence than the latter.
Neuropathy, nephropathy, and retinopathy are instances of microvascular difficulties, while CVD disease, stroke, and coronary artery illness are instances of macrovascular problems (PAD).
DKD is characterized by albuminuria (>30 mg/g urinary albumin elimination) and incremental glomerular filtration rate (GFR) decrease in the presence of long-term DM (>10 years’ period of type 1 diabetes; may be present at diagnosis in T2 DM) and is often correlated with retinopathy.
The present study had been carried out to study the association between MicroRNA 192 and 29c and diabetic kidney disease within a sample of Egyptian men and women with T2DM and DKD assessed by fasting blood glucose, HbA1c, serum creatinine and urinary Albumin /creatinine ratio (uACR)
This study was conducted on 100 total sample divided as 50 Study Cases group subdivided to DM free group and DM with DKD group) and 50 Control who were exposed to the following: full history compelling, comprehensive corporal investigation, workshop assessment including: fasting blood glucose, HbA1c, liver function test, serum creatinine, urinary albumin/creatinine ratio, estimated GFR using CKD-EPI equation and molecular studies including detection of circulating Micro RNA 192 and 29c using PCR.
The results showed that non analytically important alterations were observed among the studied groups concerning age, gender plus liver function [ALT and AST].
Serum creatinine level is significantly higher in T2DM with DKD group than T2DM Free and control group.
The mean of both Urine albumins to creatinine ratio (UACR) and estimated glomerular filtration ratio (eGFR) was significantly lower among patients in DM free and DKD groups than controls.
MicroRNA 192 and 29c are significantly high in T2DM DKD group in comparison to T2DM free and control group.