الفهرس 
Aim of the workOnly 14 pages are availabe for public view
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Abstract
Neonatal Sepsis is a life-threatening condition with significantly high level of mortality in both preterm and term infants. Roughly, it can be defined as a systematic inflammatory response that develops as a result of proven or suspicious infection in neonatal period. In developing countries, early diagnosis and treatment of babies with infections are insufficient.
Recently, 2 blood cell subtype ratios, the neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR), have been reported as useful systemic inflammatory markers and prognostic indicators of adverse cardiovascular events and cancer. The neutrophil to lymphocyte ratio (NLR), because it combines neutrophils and lymphocytes in the calculation, is considered comparatively more stable than the absolute counts. The neutrophil to lymphocyte ratio has been reported as a predictor of severity and clinical outcome in patients with community acquired pneumonia or bacteremia.
This study aimed to evaluate the value of neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) as diagnostic adjunct tests for neonatal early-onset sepsis (EOS) in term neonates. A case-control study was conducted on 100 neonates diagnosed with EOS at Neonatal Intensive Care Unit (NICU) and 50 controls of Menoufia University Hospital.
This cross-section case-control study was conducted at Neonatal Intensive Care Units (NICUs) of the Pediatric Department at Menoufia University Hospital from December 2019 to February 2021. The goal of this study was to see how useful the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are for early diagnosis of newborn early-onset sepsis in term AGA infants. This study was carried out on 150 terms AGA, neonates, they divided into two groups as patients’ group included 100 septic terms, AGA, neonates with clinical and lab evidence of EOS, as well as control group included 50 healthy terms, AGA, neonates with no clinical, or laboratory evidence of sepsis. Full history taking, full clinical examination for all neonates included in this study and the laboratory investigations were done for all cases as complete blood count (CBC), Immature to a total neutrophil ratio (1/T ratio), neutrophil to lymphocyte ratio (NLR), Platelet to lymphocyte ratio (PLR), C-reactive protein (CRP) and Blood culture.
Results of the current study could be summarized as follows:
There was statistically significant difference between patients’ group and control group regarding mode of delivery, (p=0.038). While, no differences regarding maternal age, gender, gestational age, birth weight, length and HC (p>0.05).
37% of the studied patients had apnea and distention. While (40%) of them had cyanosis. Also, (77%, 90%, 50%, 39%, 18%) of the studied patients