الفهرس 
Synthesis, characterization and Evaluation of the Therapeutic Effect of Zinc Oxide Nanocomposite on Hepatocellular Carcinoma in Male Albino Rats
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Abstract
Infection with hepatitis viruses or exposure to chemicals may cause an increase in the number of liver patients as a result of hepatotoxicity, which leads to cell damage and chronic inflammation in liver cells, where the liver is responsible for drug metabolism and disposal of toxic substances. Diethylnitrosamine (DEN) and carbon tetrachloride (CCl4) stimulate the production of free radicals, which leads to cell oxidation and tissue destruction. Oxidation processes can be inhibited by using antioxidants extracted from plants, herbs, fungi and bacteria. Hepatocellular carcinoma is a common liver cancer type and some patients have resistance for chemotherapy, radiation or synthesitic drugs.The current study aims to make a scientific comparison from the biological and biological point of view to study the effect of ZnO@SPION@Ag nanocomposite and sorafenib loaded on ZnO@SPION@Ag nanocomposite nanoparticles as an antioxidant at a dose equivalent to 10 mg/Kgb.wt. in comparison with treatment with sorafenib as a widespread common drug for hepatocellular carcinoma in rats experiments. Nanocomposite was prepared by using fungus, which make a reduction for silver and deposite it on iron then dry. Zinc oxide nanoparticle was prepared and loaded on the first nanoparticle core shell then loaded by sorafenib and characterization was done by different techniques