الفهرس 
TitleOnly 14 pages are availabe for public view
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Abstract
Osteoarthritis (OA) is the most common degenerative disorder of synovial joints
marked by articular cartilage erosion. The majority of current therapies targeted only OA
symptoms, and still there is a need for treatments that decrease pain and improve the cartilage
function.
Alginates (ALG) are a family of naturally abundant anionic polysaccharides extracted
from the cell walls of the brown algae, they are one of the increasingly studied ones in the
biomedical and pharmaceutical researches and its monograph is included into both the
European Pharmacopeia and the United States Pharmacopeia
This study directed to show the alginate ameliorative effects on MIA-induced
osteoarthritis in rats, Our study was carried on 77 rats divided into three groups as follows
group 1: 28 male rats apparently healthy representing the control group, group 2: 28 male
rats were subjected to a single intra- articular dose of MIA , group 3 : 21 male rats treated
with alginate
Histopathological results showed that Intra-articular injection of MIA by 2 weeks,
induced joints arthritis which had a mild focal fissuring in the upper third, disorganization of
chondrocytes and focal chondroid hyperplasia and Neovascularization of the matrix, with an
increase in aggrecanase, β-glucuronidase, and hyaluronic acid and a decrease in the level of
glutathione when compared with that of the control
Reduced glutathione levels were found to be significantly decreased in rats with
osteoarthritis than in control due oxidative stress involved in pathogenesis of OA which
results due to elevated free radical production.
Histopathological examination from our study evident that the alginates produce antiinflammatory
effect which showed by the high decreases in the enzymatic activities level of
β-glucuronidase and aggrecanase and hyaluronic acid
Alginate treatment results in reduction of the enzymes aggrecanase, β-glucuronidase
which indicate decrease in cartilage degradation.
6.2. Recommendations
(1) Our present study recommended that the Brown algae could produce an ameliorative
effect on OA.
(2) Further studies should be done in mammals to provide more insights into the
underlying mechanisms and to determine the highly effective components in alginate
that could have maximum therapeutic efficacy with minimum side effects.
(3) The inflammatory markers can be used to predict disease development and treatment
success such as ( β glucouronidase ) .
(4) Hyaluronic acid and aggrecanasecan be excellent biomarkers of osteoarthritis
progression.