الفهرس | Only 14 pages are availabe for public view |
Abstract Background: Vitiligo is an acquired, multifactorial disease of the skin and mucous membrane characterized by depigmented macules. It can be mainly differentiated into segmental and non-segmental vitiligo. Diagnosis is mainly by clinical examination and wood’s light. There are several treatment modalities among which are systemic and local medications, phototherapy, lasers, surgical interventions and camouflage. Dermoscopy is an important diagnostic and follow up tool in dermatology clinics. In this study we assessed the value of dermoscopy in evaluation of four different treatment modalities in vitiligo patients. Subjects and Methods: This study was carried out on 60 patients who were divided into four groups of 15 patients each according to treatment modality used: Dermabrasion with Erbium Yag laser then application of 5Fluro- Uracil cream. Topical Immunomodulator. Excimer light. NBUVB. Four visits were documented for each patient (before treatment, after one week, after one month and after 3 months).Photographic and dermoscopic documentation were done each visit. We decided to emphasize on five main findings (Erythema, Hair color, repigmentation, peri-lesional hyperpigmentation and telangiectasia). Results: Before treatment, all patients of different groups (60 patients) combined showed a high statistically significant difference between Photography and dermoscopy regarding hair color detection and telangiectasia in favor of dermoscopy. Erythema showed statistically significant difference between Photography and dermoscopy after 1 st week with excimer light, and after 4 th and 12 th week with dermabrasion+5fu. Hair color showed statistically significant difference between Photography and dermoscopy in the 1 st , 4 th , and 12 th weeks with dermabrasion+5fu and excimer light. Telangiectasia showed statistically significant difference between Photography and dermoscopy in the 1 st , 4 th and 12 th weeks with dermabrasion+5fu, Elidel cream and excimer light.There was also a high statistically significant difference between dermabrasion+5fu in comparison with other groups regarding erythema after 1 st week by both photography and Dermoscopy. There were also a couple of special findings along the way like blue vitiligo, hair repigmentation and proof of false unresponsiveness by naked eye. |