الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Acne vulgaris is a common chronic skin disease involving blockage and/or inflammation of pilosebaceous units (hair follicles and their accompanying sebaceous gland). Acne can present as non-inflammatory lesions (open or closed comedones), inflammatory lesions (papules, pustules, and nodules) or a mixture of both typically affects the areas of skin with the densest population of sebaceous follicles, these areas include the face, the upper part of the chest, and the back.
Acne vulgaris is a benign self-limited condition. However, patients usually endure anxiety, depression, poor body image, frustration, anger, diminished confidence and self-esteem, social isolation, and restriction of activities because it commonly affects the face during a socio-sexually critical age causing a considerable cosmetic concern with adverse social and psychological consequences on the quality of life as regard to social and academic performance.
Neurotrophins (NTs) are secreted growth factors that regulate neuronal differentiation, survival, growth, synaptic formation, and plasticity. There are four types of neurtrophins that have been characterized in mammals including neural growth factors (NGF), Brain derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4).
In the normal cells, BDNF as a certain neuron helps to support the survival of existing neurons in both central and peripheral nervous system, and resulting the growth and differentiation of new neurons and synapses.
Brain-derived neurotrophic factor signaling might be involved in affective behaviors as environmental stresses which cause depression and also decrease BDNF mRNA, while physical exercise decreases depression and increases BDNF mRNA.Although it was found that BDNF could be involved in the pathogenesis of some skin disorders which are exacerbated by stress such as psoriasis,vitiligo and acne vulgaris.