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Abstract Acne vulgaris (AV) is a cutaneous chronic inflammatory disorder with complex pathogenesis. It is characterized by the development of seborrhea, comedones, nodules, papules, pustules and cyst. It comes in the areas of the skin with plentiful hair growth such as in the upper chest, back and face. Triggering causes of acne include (use of medications like lithium, steroids and anticonvulsant- exposure to excess sunlight - use of occlusive wear like shoulder pads, headbands, backpacks and underwire brassieres - endocrine disorders like polycystic ovarian syndrome and even pregnancy). Acne occurs due to hypersensitivity of the sebaceous glands to a normal circulating level of androgens which are aggravated by P. acnes and inflammation. Chitinase-3 like protein -1 is an inflammatory glycoprotein associated with atherosclerosis, cardiovascular disease, diabetes and metabolic syndrome which are common comorbidities in psoriasis. The relation between lipid profiles and acne is not widely investigated. YKL-40 might have a role in AV pathogenesis. In addition, it could provide a new potential link between inflammation and dyslipidemia observed in acne patients. The aim of this study was to evaluate the possible role of YKL-40 as an important inflammatory marker involved in AV and its potential relation with disturbed lipid profile in those patients. Study was conducted on 40 patients suffering from AV (group A) and 40 apparently healthy individuals of matched age and sex as a control group (group B). Patients were recruited from the outpatient clinic of Dermatology and Andrology Department of Menoufia University Hospitals. Study was approved by the Local Ethics Committee of Menoufia Faculty of Medicine. Informed consent was obtained from each individual before being enrolled in the study. |