الفهرس 
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Abstract
Summary
Hepatocellular carcinoma (HCC) represented the prevalent challenging dilemma that increased dramatically among various ethnic populations, particularly among Egyptians.
In earlier years, the higher prevalence of liver-associated cancers in Egypt is raised among men compared with women and signified the first reason for higher mortality. However, the origin of the molecular pathogenesis of HCC persists ambiguous, although the contribution of various environmental, genetic, and epigenetic factors in the progression of the disease.
The DNA repair genes have a crucial function in the base excision repair (BER) mechanism among different cancerous disorders, particularly hepatocellularcarcinoma.
The foremost objective of our study is to explore the association of the APEX1 p.Asp148Glu and the XRCC1 p.Gln399Arg variants with the susceptibility of hepatocellular carcinoma and to identify the computational bioinformatics frameworks of these missense variants.
The hospital-based case-control work is conceived based on 250 participants, involving 150 HCC patients [76.7% males, and 23.3% females], and 100 cancer-free controls [74.0% males, and 26.0% females]. At the beginning of this study, handwritten consent was achieved from all participants before their enrollment in this assessment.
The diagnostic imaging of HCC patients including the multiphase magnetic resonance imaging (MRI), and/or computerized tomography