الفهرس 
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Abstract
AKI is a fatal complication after trauma, which presented with a high mortality in
the studied population. The causes of AKI in trauma patients are multifactorial
and more effective measures of prevention and treatment of AKI in this population
are urgently needed.
Our aim of this study was to; define and determine the incidence of Acute
Kidney Injury (AKI) based on Kidney Disease Improving Global Outcome
(KDIGO) criteria in Severe Trauma patients admitted to ICU , and to identify
predictors of Acute Kidney Injury and the outcomes of AKI after trauma.
This study was carried out on 116 patients who presented to the Emergency
Department in a trauma event, Menoufia University Hospitals, during the period
from April 2019 to october 2020.
Data were collected in pre-organized data sheet (Case Sheet) by the researcher;
from patients fulfilling inclusion and exclusion criteria . Demographic data and
characters of studied population , data related to trauma , Initial Vital signs , data
to detect AKI using KDIGO Criteria , data collected to detect the risk factors ,
data concerning outcome.
The study describes the incidence, risk factors and outcomes of AKI , as defined
by the KDIGO criteria , in a population of injured patients . 33.6 % of patients
developed AKI following injury , with 9.5 % requiring renal replacement theraby .
Independent risk factors for trauma-induced AKI were greater injury severity
(ISS) , shock , higher admission serum creatinine , sepsis , mechanical ventilation , higher admission serum CK , administration of nephrotoxic therapy and other
more variables . Furthermore, the development of AKI was an independent risk
factor for death and associated with an increase in mortality.
In our study we found that , the mean age of patients presented to ED in a trauma
event, it was 37.28±14.30, where males were more than females (88 and 28
respectively). Also, it shows that some patients had comorbidities (such DM,
HTN, cardiac and chest history, tumors) that affected on their outcomes.
Most of them presented by blunt trauma (94.8%). Also it shows the primary triage
of the patients , in which the Mean ± SD of respiratory rate, MAP at time of
admission, pulse, GCS was 20.5±5.11, 77.55±22.91, 97.45±27.26, 9.85±4.7
respectively, and that of ISS, APACHE was 29.91±10.97, 13.08±7.64
respectively, and the follow up of all studied patients were done in ICU.
In our study we found that , there was a significant difference (p value = 0.026)
between patients developed AKI and those without AKI regards only the
number of comorbidities.