الفهرس 
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Abstract
Psoriasis is a chronic, recurrent, immune-mediated inflammatory disease that affects 1-3% of the world population and characterized by well-demarcated erythematous plaques with adherent silvery scales. The most frequent areas of involvement include the elbows, knees, lower back, and buttocks but the disease can involve any cutaneous surface. Variations in the morphology of psoriasis have been classified into several clinical subtypes as plaque psoriasis, guttate psoriasis, erythrodermic psoriasis, psoriatic arthritis and pustular psoriasis. The pathogenesis is not known but it is mostly the outcome of interplay between different factors including genetic, metabolic and environmental triggers.
Signal peptide-CUB-Epidermal growth factor like protein is a newly identified protein family containing three members, SCUBE1, SCUBE 2, and SCUBE 3. SCUBE is significantly expressed in the majority of vascularized tissues, as well as primary osteoblasts and bones. SCUBE levels increases can be detected in inflammation- and hypoxia-associated disease conditions. Studies have demonstrated crosstalk with angiogenesis-linked molecules, including hedgehog.
The aim of this work was to determine possible role of SCUBE1 in psoriasis by measuring it in the serum of psoriatic patients and to correlate its level with the available clinical data.
This case- control study was conducted on a total number of 90 subjects; 45 patients with psoriasis vulgaris as a patients group beside 45 age and sex matched healthy subjects as a control group.
Exclusion criteria included Patients with a history of acute coronary syndrome, Cerebrovascular event, Recent myocardial
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infarction (<3 months), Heart failure, Acute severe infection, Other autoimmune or inflammatory disorder and Other dermatological diseases than psoriasis vulgaris.
Every patient was subjected to history taking regarding, complete general examination, dermatological examination and assessment of psoriasis severity by psoriasis area severity Index (PASI) score.
In the current study patients were 29 (64.4%) males and 16(35.6%) females with an M: F ratio of 1.8: 1. Their age ranged from 10 to 50 years with 43.53 ± 18.69 as a mean ± SD value. Control group included 26(57.8%) males and 19 (42.2%) females with an M: F ratio of 1.3: 1. Their age range from 9 to 48 years with 42.98 ± 18.55 as a mean ± SD value without significant difference between both in age and gender as p=0.517 &0.888 respectively.
psoriasis area severity Index score ranged from 3.7 to 57.6 with 21.61± 16.21 as a mean ±SD value. Regarding disease severity, 5 (11.1%) cases were with mild psoriasis, 9 (20%) cases were moderate and 31 (68.9%) cases were severe psoriasis.
There was higher level of mean serum SCUBE1 among cases was statistically significant compared with controls (13.38 ± 25.63 versus8.69 ± 19.28, P<0.014).
There were statistically non-significant relationships between mean serum level of SCUBE 1 and clinical data of the studied cases as onset, course, risk factors, family history, site of affection, scalp, palm, sole, joint & nail affection and Kobnerization (p>0.05 for all).
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There were statistically non- significant positive correlations between serum SCUBE1, age of the patients in years, duration of disease in years and PASI Score.
Signal peptide-CUB-EGF domain-containing protein 1 is a significant good predictor for diagnosis of psoriasis versus control at a cut off value of >3.97 ng/ml and having 0.651 area under a curve (AUC). (95% C.I 0.538 – 0.764), 66.67 sensitivity and 62.22 specificity.