الفهرس 
Embryological Development of BrainOnly 14 pages are availabe for public view
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Abstract
Neonatal encephalopathy is a heterogeneous syndrome characterized by signs of central nervous system dysfunction in newborn infants. Clinical suspicion of neonatal encephalopathy should be considered in any infant exhibiting an abnormal level of consciousness, seizures, tone and reflex abnormalities, apnea, aspiration, feeding difficulties, and an abnormal hearing screen.
Neonatal encephalopathy continues to be an important cause of neonatal mortality and morbidity in the United States. Hypoxic-ischemic injury (HII), which is also known as hypoxic-ischemic encephalopathy, refers to the subset of neonatal encephalopathy that result from a hypoxic or ischemic event, often in the setting of perinatal asphyxia, which leads to hypoxemia and hypercapnia. The common pathophysiologic processes that result in hypoxic ischemic injury are diminished cerebral blood flow (ischemia) and reduced blood oxygenation (hypoxemia).
Magnetic resonance (MR) imaging is the most sensitive technique for depicting the developing brain, because it can provide highly detailed images of brain structures without exposing infants to ionizing radiation and associated health risks. Magnetic resonance (MR) imaging is used with increasing frequency to evaluate the neonatal brain because it can provide important diagnostic and prognostic information that is needed for optimal treatment and appropriate counseling.
This study aimed to throw light of the predictive value of MRI as a safe and superior neuro-imaging technique in cases of hypoxic ischemic encephalopathy.
To elucidate our aim, this study was conducted on 30 neonates with hypoxic ischemic encephalopathy referred to radiology department at Menoufia University Hospitals for advanced magnetic resonance techniques assessment during the period from July 2019 to December 2020.
Our results showed that:
• Regarding MRI findings, (46.67%) of the studied participants had periventricular leukomalacia, (36.67%) had basal ganglia ischemia, (36.67%) had focal encephalomalacia. Also, atrophic changes found in 9 participants (30 %), intraventricular hemorrhage presented in 5 participant (16.67%) and restricted diffusion weighted in 10 participants (33.33%).
• This study also found that Periventricular leukomalacia and basal ganglia ischemia were significantly related with diffusion weighted (p<0.05)