الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Vitamin D is mostly known for its essential role in the musculoskeletal system especially in Calcium and phosphorus metabolism. Emerging evidence supports that VD is involved in glucose homeostasis and contributes to the pathophysiology of insulin resistance and diabetes mellitus. Aim of the work: to assess the 25-hydroxy vitamin D3 [25(OH)D3] status among adults with Type 1 & Type 2 DM patients and its correlation with glycemic control and microvascular complications.Subjects and methods: This study included 140 adult diabetic subjects, divided into 2 groups: group (1): 100 T2DM patients, group (2): 40 T1DM patients. In addition to group (3): forty non diabetic healthy control subjects.The study revealed the following results:(1)Serum vitamin D is significantly lower in diabetic patients than normal subjects.(2)Vitamin D deficiency is comparable in type 1 and type 2 DM. (3)Vitamin D deficiency is more prevalent in diabetic patients with microvascular complications than those without complications.(4)Serum vitamin D is significantly lower in uncontrolled diabetic patients compared to controlled diabetic patients.(5)Vitamin D has a significant negative correlation with FBS, HBA1C and with microvascular complications.(6)Vitamin D deficiency was independent predictor for poor glycemic control.(7)The cutoff value of serum vitamin D ≤16.8 ng/ml predicted poor glycemic control with sensitivity, and specificity of 87.8%, and 57.1%, respectively. Conclusion: low vitamin D level is highly prevalent among diabetic patients, particularly among patients with poor glycemic control and in those who have microvascular complications. This support the hypothesis that the correction of coexistent low 25-OHD levels may be an important step in the management of DM and in the prevention of its complications.