الفهرس 
Sickle cell anemiaOnly 14 pages are availabe for public view
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Abstract
Sickle cell disease is a spectrum of disorders of the red blood cell, sickle cell disease (SCD) is one of the most common hematologic disorders associated with neurological disease in children.
Neurological complications such as overt hemorrhagic and ischemic stroke and silent cerebral infarctions (SC occur with increased frequency in the pediatric SCD population).
There is a growing evidence for the role of BDNF in the survival, differentiation and plasticity of neurons throughout the brain and spinal cord.
BDNF has been associated with neuroprotection in ischemic brain injury and may provide prognostic and diagnostic information in traumatic and ischemic brain injury.
This study was conducted on 35 patients with documented sickle cell disease, from Hematology unit, Pediatric department, Menoufia University hospital their ages were from 2-18 years and 35 apparently healthy children with age, sex and socioeconomic standard matched as a control group.
Full history (personal, present, past and family history: especially age, sex, consanguinity, splenectomy, frequency of blood transfusion, crises and pain rate per year) and complete physical and clinical examination were taken.
Laboratory evaluation in the form of: complete blood count (CBC), serum urea, creatinine, AST, ALT, hemoglobin electrophoresis and serum ferritin. Transcranial Doppler was done to all patients and MRI was done to high-risk groups. Serum