الفهرس 
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Abstract
Abstract
Objective: Using data collected and statistical study findings, this study will assess the relationship between tumour human papillomavirus (HPV) status (as an independent prognostic factor) and invasive cervical cancer (ICC) prognosis..
Methods: This retrospective registry and follow up study was conducted on 95 women diagnosed as cervical cancer. HPV testing by immunohistochemistry for p16/inka4 was performed on a fairly representative sample of all participating cancer cervix registry, then 50 cases were categorized into two groups; group 1: HPV positive and group two: HPV negative then prognosis was assessed from comparing follow up data of both groups.
Results: focal nuclear ranged from 0.10-0.90 % with mean of 0.49±0.29%. There were 40 (80.0%) patients with positive overall P16 expression. There were insignificant differences between positive group and negative group as regards tumor size (< 5 cm vs > 5 cm), Figo staging (1 or 2 vs 3 or 4), pre-existing lesion (no vs yes), final histology type (SqCC vs other types), LVI (negative vs positive), LN (negative vs positive) and metastasis (negative vs positive). Positive LN was significantly increased in positive group compared to negative group (71.4% vs 28.6%, P value = 0.02). Grade 2 was significantly higher compared to grade 3 group (0.64% vs 0.35%, P value = 0.03). Tumor size was significantly increased in positive group compared to negative group (91.7% vs 8.3%, P value = 0.05).
Conclusion: P16 expression was higher in HPV positive cases relative to HPV negative cases, but there was no association between P16 expression (block positivity and focal nuclear) and clinicopathological tumor parameters or progression free survival (PFS) or overall survival (OS).