الفهرس 
Inflammation and End Stage Kidney DiseaseOnly 14 pages are availabe for public view
 |  | from | 112 |  |  |
| | | from | 112 | | |
Abstract
Abstract
Background .The neutrophil-lymphocyte ratio (NLR) and monocyte-lymphocyte ratio (MLR) in peripheral blood are used as indicators of systemic inflammation and predictors of cardiovascular diseases.
Aims . To study the relation between both NLR and MLR and the prediction of CV events in ESRD patients on regular hemodialysis (HD).
Patients and Methods. 70 ESRD patients on regular HD were followed up for 12 months. NLR ,MLR , their individual components were determined at baseline and in the follow up months. The changes in NLR and MLR after 12 months were compared. High sensitivity C-reactive protein (hs-CRP) and echocardiography studies were done at baseline and after 12 months. Major cardiovascular events (CVE) were recorded.
Results. Total leucocytic, absolute neurophil and monocyte counts were significantly increased over time. The presence of valvular calcification was associated with an increase in both NLR and MLR(p 0.004 and 0.001 respectively) after 12 months. The mean monocyte counts were significantly higher in patients with CV complications. The baseline monocyte count was the best to predict CV complications with a cut off point >0.54 103/ul (sensitivity 100%, specificity 73.85%) in the ROC curve.
Conclusion. In ESRD patients, leucocytic counts are in a dynamic change. There was no significant change in NLR or MLR over time and their changes could not predict occurrence of CVE. The monocyte count is an excellent predictor of CV diseases. The presence of valvular calcification is associated with increases in both NLR and MLR over time.