الفهرس 
Polymer development over time
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Abstract
The goal of this work was to make anticancer materials out of modified polymers like pluronic and tetronics, as well as to look into the hazardous effects of synthetic P-HBAminated Pluronic, N,N DMABAminated Pluronic, P-HBAminated Tetronic and N,N DMABAminated Tetronic on HepG-2 cancer cells in-vitro compared to chemotherapeutic drug such as Doxorubicin. N,N DMABAminated Pluronic, P-HBAminated Tetronic and N,N DMABAminated Tetronic are type of modified aminated polymers in the Poloxamers and Poloxamines families, were prepared by Schiff base method and used as anticancer materials compared to DOX. Fourier transform infrared spectroscopy (FTIR) and zetasizer were used to assess the physico-chemical characteristics of these modified aminated polymers. characterization of modified aminated Poloxamers and Poloxamines showed that N,N DMABAminated Pluronic is in nano size form. In vitro study revealed that N,N DMABAminated Pluronic significantly reduced viability of Hepg-G cells. Flowi cytometry was used to measure the DNA content of HepG-2 cells during their cell cycles, using the PI (Propidium iodide) fluorescent dye. All modified Aminated Poloxamers and Poloxamines did not show anticancer effect on HepG-2 cells except N,N DMABAminated Pluronic, In terms of cell cycle arrest, we discovered that N,N DMABAminated Pluronic arrested the cell cycle at Go phase 63.9 percent of the time, but DOX only arrested the cell cycle at Go phase 39.1 percent of the time. The use of (AnnexinV– PI) to analyze apoptosis in Hepg-2 cells revealed that N,N DMABAminated Pluronic significantly enhanced apoptosis in late apoptosis.