الفهرس 
T YPE 1 D IABETES M ELLITUSOnly 14 pages are availabe for public view
 |  | from | 151 |  |  |
| | | from | 151 | | |
Abstract
Background: Children with type 1 diabetes (T1DM) are at risk of glycemic deterioration during the COVID-19 pandemic due to several factors. However, some studies reported glycemic improvement in these children during the COVID-19 pandemic. Aim: To assess the impact of COVID-19 on children with T1DM in Egypt in terms of glycemic control and insulin therapy. Methodology: Forty-two children with T1DM on insulin pump for at least 3 months were recruited from the Pediatric and Adolescent Diabetes Unit (PADU), Ain-Shams University. They were assessed for insulin requirements, insulin pump problems, frequency of follow up and frequency of diabetic ketoacidosis and clinically significant hypoglycemias, quality of life, exercise and depression. Auxological parameters, HbA1C and lipid profile were assessed. Continuous glucose monitoring was done using Medtronic i-pro device for 5 days or each patient. Data were compared to previous patients data obtained from the patients’ medical records. Result: The mean insulin requirements of the studied children with T1DM on insulin pump before the COVID-19 pandemic was 0.83 ± 0.28 U/kg/day, range 0.5- 1.8 with a mean basal percentage of 51.19 ± 3.46 U/kg/day, range 45-60. There was statistically significant increase in the total daily insulin units(P=0.001), basal percentage (P=0.011) with a significant decrease in the frequency of DKA (P=0.001) and hypoglycemia (P=0.004) after the COVID-19 pandemic. Conclusion: Glycemic control improved during the COVID-19 pandemic among children with T1DM.