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العنوان
The Assessment of Immunological Status in Hemodialysis Patients Post COVID-19 Infection /
المؤلف
Elkholy, Enas Fathe Hassan.
هيئة الاعداد
باحث / ايناس فتح حسن الخولى
مشرف / هويدا عبدالحميد الشناوي
مشرف / هيام محمد عارف
مشرف / مصطفى عبدالنصير عبد الجواد
تاريخ النشر
2022.
عدد الصفحات
170 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب الباطني
تاريخ الإجازة
1/1/2022
مكان الإجازة
جامعة عين شمس - كلية الطب - أمراض الباطنة و الكلى
الفهرس
Only 14 pages are availabe for public view

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Abstract

This study is aimed to Detect the level of immunoglobulin (IgG) antibodies against covid _19 viruses to assess the immunological status of the patients post covid_19 infections and their risk for reinfection with covid _19.
This study is Cohort study, was carried out Hemodialysis unit in Nephrology department, Ain shams university Hospital and Ain shams specialized Hospital, on 60 of heamodialysis patients divided into these three groups; (group 1): included 20 patients that have been infected with covid 19 and confirmed positive by PCR test, (group 2): included 20 patients who were highly suspected infection with covid_19 by CT findings, (group 3): included 20 patients with no history suggestive of covid_19 infection during the pandemic as acontrol study group.
The main results of the study revealed that:
there is no significant statistical difference between patients in group A (who are confirmed positive covid 19 infection by pcr test) and group B (who are suspected covid infection by ct or symptoms and laboratory findings) and group C (who are not infected or have symptoms) as regard age, sex and smoking (p- value >0.05).
there is no significance between patients in group A and group B and group C as regard the cause of end stage renal disease and duration of dialysis.
there is no significance between patients in group A and group B and group regards BMI, HTN, DM, HBV or other comorbidities.
there is astrong significance between between patients in group A and group B and group C as regard hospital admission and home isolation.
there is asignificance between patients in group A) and group B (and group C as regard IgG titre.
there is a significance between patients in group A and group B and group C as regard lymphocyte count during infection, and shows that there is no significance between the groups as regard (HB,MCV,MCH,MCHC,WBCS,Platelets).
there is a significance between patients in group A and group B and group C as regard duration of hospital admission, But there is no significance between the groups and duration from infection till the sampling.
in all the patients there is a significantly negatively correlation between IgG titre and lymphocytes count during infection and significance negative correlation between IgG titre duration from infection and there is a significance negative correlation between duration of hospital admission and lymphocytes count during infection.
there is significance negative Correlation of IgG Titer and hospital admission duration with lymphocytes count during infection and duration form infection respectively in COVID patients confirmed by PCR (n= 20).
significance positive Correlation of IgG Titer with age and there is a significance positive correlation of hospital admission duration with BMI in COVID suspected patients by CT (n= 20).
no Correlation of IgG Titer with any factor in group C (non-COVID patients) (n= 20).
there is a significance between duration of infection and IgG titre as patients who were 3 months from infection have strong significans more than who were 6 months or more from infection, and there is no significance between duration of infections and labs findings.
There is significance between IgG titre and duration from infection in group A and group B if the duration of infection was less than 6 months or more than 6 months.