الفهرس 
Bronchial asthmaOnly 14 pages are availabe for public view
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Abstract
Trace elements (Zinc, Iron Copper) and Magnesium are essential micronutrients, which play a vital role in the body to perform its functions properly. Abnormal levels of trace elements may be associated with production of free radicals with subsequent tissue damage and infectious diseases. Reactive oxygen free radicals play a role for the pathogenesis of bronchial asthma, which is a chronic inflammatory disease of the respiratory tract. There are some antioxidant enzymes to avoid the harmful effect of free radicals. These enzymes) responsible for antioxidant defense ( have trace elements like zinc (Zn), copper (Cu) and Iron (Fe) within their structure and act as a cofactor for these enzymes. The antioxidant mechanisms that protect the lung against these oxidants include: superoxide dismutases and glutathione peroxidase.
Changes in the level of these trace elements decrease the efficiency of antioxidant systems and this leads to hyper-reactivity and inflammation in the respiratory tract. There exists an imbalance between oxidants and antioxidants in allergic asthma causing inflammatory processes in the airways. It is not clear whether magnesium (Mg) deficiency plays a role in the development of asthma, but magnesium salts have a therapeutic role as an adjunct to traditional therapy of asthma.
The aim of our work is to determine the concentrations of the trace elements (Cu, Zn, Fe) and Mg in sera of adult asthmatic patients and to evaluate their value in ashma severity and control.
This study was done on 71 adult asthmatic patients (37 males, 34 females) and 20 age and sex matched subjects ((8 males, 12 females) were included as a control group. Patients were attendants of outpatient chest clinic of Menoufia University Hospitals in the period from January 2019 to December 2019.An informed consent was taken from all subjects and approval of Ethical Committee of Menoufia University was taken.