الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
The pathophysiology of vitiligo is complex although recent re-search has discovered several markers which are linked to vitiligo and associated with disease activity. Besides providing insights into the driv-ing mechanisms of vitiligo, these findings could reveal potential biomarkers.
Stress associated endoplasmic reticulum protein 1 (SERP1), also known as ribosome-associated membrane protein 4 (RAMP4), can cause accumulation of unfolded proteins in ER stress.SERP1 was reported to interact with subunits (Sec 61α and Sec 61β) of the translocon, which acts as a channel and mediates the translocation of polypeptides across membranes to aid protein synthesis. Thus, SERP1 is implicated in the regulation of membrane protein biogenesis. SERP1 overexpression caused the newly synthesized integral membrane proteins to degrade, and then facilitated protein glycosylation in order to protect cells from ER stress.
The cross talk between oxidative stress, ER stress and autoimmunity appears crucial and may emerge as a critical aspect of vitiligo pathogenesis. SERP1 is new marker that increases in patients with vitiligo. In the current study we found that tissue expression of SERP-1 was significantly higher in Vitiligo skin lesions in patients with positive as compared with negative family history; however no statistically significant difference was detected regarding SERP-1 tissue expression and family history and a significant linear moderate negative correlation between tissue expression of SERP-1and history of disease duration in studied Vitiligo patients.
Based on our findings, we recommend for further studies on larger sample size and on large geographical scale to emphasize or conclusion.