الفهرس 
Aim of the StudyOnly 14 pages are availabe for public view
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Abstract
Non-alcoholic fatty liver disease (NAFLD) is a major public health issue
due to its high prevalence worldwide and potentially serious sequelae.
Nonalcoholic fatty liver disease (NAFLD) is characterized by the presence
of extra fat in the liver, exceeding 5–10% of liver weight. Most patients with
NAFLD have increased liver fat only (simple steatosis). Some of the patients
develop hepatic inflammation, a condition known as nonalcoholic steatohepatitis
(NASH), and up to 20% of patients experience progressive hepatic fibrosis and may
eventually progress to liver cirrhosis or failure and even hepatocellular carcinoma.
The gold standard for NASH diagnosis is liver biopsy. This procedure,
however, is invasive, overpriced, and associated with rare but potentially risky
complications and sampling errors; hence, it is not appropriate as a screening tool.
One of the imaging techniques which are used as noninvasive diagnostic test
for NAFLD is ultrasonography, by which the incidence and severity of fatty liver
are measured by grading of fatty liver (Grade 1, 2 and 3) according to the
hyperechogenicity of the liver tissue, the divergence between liver and diaphragm
and the visibility of vascular structures.
The aim of the study is to evaluate circulating selenoprotein P (SEPP) levels
in patients with nonalcoholic fatty liver compared with healthy controls.
This is a retrospective study that was conducted on 72 patients (60 males
and 12 females) with NAFLD (cases), and 36 healthy volunteers (25 males and 11
females) without NAFLD or any chronic liver disease as controls cross matched
with patients in age and sex in the period between April 2019 to March 2020. The
mean ± SD ages of patients and controls were (48.38 ± 7.24) years and (46.11±6.72)
years respectively. All subjects (cases and controls) had been collected from
outpatient clinics of the GI department of Menoufia university hospitals and the
controls are members of staff of the hospital.
The main results of the study revealed that:
There was no significant difference between groups regarding age nor gender.
There was significant difference between groups regarding BMI and Waist
circumference.
There was significant difference between groups regarding liver function
tests.
There was no significant difference between groups regarding Urea but there
was significant difference between groups regarding creatinine.
There was significant difference between groups regarding Glucose, Insulin
and HOMA-IR.
There was highly statistical significant difference between groups regarding
to serum Serum selenoprotein P.
There was positive correlation between SEPP levels and both creatinine and
Log (GGT), and negative correlation between SEPP levels and (glucose,
insulin, (HOMA-IR) and BMI).
In conclusion, Selenoprotien p concentrations were decreased in subjects
with NAFLD than normal healthy subjects.
Finally, we recommend for further studies on large geographical scale and
on larger sample size to emphasize our conclusion.