الفهرس 
Aim of the workOnly 14 pages are availabe for public view
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Abstract
Childhood obesity is a serious public health problem associated with the development of several chronic diseases .
The etiology of obesity is extremely complex being influenced by environmental, behavioral and genetic factors.
IGF-1 is a 70 amino acids polypeptide with autocrine, paracrine, and endocrine properties, and is considered to play key roles in fetal development and growth up to adolescence, and in the maintenance of homeostasis in adult tissues by regulating cell proliferation, differentiation, and survival. It has also been reported IGF-1 has atheroprotective, neuroprotective, and insulin-like effects and that it regulates skeletal muscle metabolism and regeneration.
Studies on the Growth Hormone- Insulin like growth factor (GH-IGF) axis in obese subjects have generated conflicting results. Normal and reduced GH secretion have been reported in association with normal, reduced, and high levels of IGF-I . The majority of IGF-I actions are mediated by its interaction with the IGF type 1 receptor (IGF-IR), which is modified by the IGF-binding proteins. GH is the main regulator of IGF-I and regulates its availability to the tissue.
The aim of the work was to study the association of insulin like growth factor -1RmRNA expression and serum insulin like growth factor-1 with obesity in children. This study included forty eighty children that were classified into 2 groups:
group 1: This group included 44 children with a BMI more than two standard deviation.
group 2: This group included 44 age-matched non-obese children.
Four milliliters venous blood were withdrawn after 12-hour fasting by venipuncture from all patients and divided as follow:
Summary
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Tube A: 2ml were added to plain tube, serum was separated then used for assay lipid profile, FBS and IGF-I level.
Tube B: 2ml were added to EDTA tube for evaluat