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Abstract A cross-sectional study design was used to evaluate the ability of color Doppler and CT to assess portal vein thrombosis. This study was carried out in Diagnostic Radiology Department at Suez Canal University Hospital on 20 patients. The patients were divided into two groups based on clinical suspicion, confirmed by images, ultrasound and color Doppler examination and tri-phasic CT evaluation. The main objectives of the study were, Comparison between the sensitivity and specificity of color Doppler and CT in assessment of PVT, and Assessment of the value of combination of CT and color Doppler in more accurate evaluation of PVT and differentiation between benign and malignant one. The method, All patients of this study were subjected to the following: 1- Thorough history taking, with special emphasis on special habits such as alcoholism, present history of hematemesis or melena, jaundice, exposure or intake of hepatotoxic drugs, previous local alcohol injection or any other local ablation for hepatic focal lesion. 2- Clinical examination, including general examination stressing on jaundice and the consciousness level, and local abdominal examination, with stressing on liver, spleen, ascites and collaterals. Laboratory investigations: including serum bilirubin, albumin, creatinine, and prothrombin activity, G.I. tumor markers including serum alpha fetoprotein and anti-HBV and anti-HCV. 3- US examination: a. Real-time US examination: with 3.5 MHz transducer for examination of the liver as regards its size, echotexture, contour hepatic focal lesion, PV, presence or absence of intrahepatic biliary radicle dilatation, porta-hepatis, abdominal lymph nodes and ascites b. Color Doppler US examination of PV: The protocol consisted |