الفهرس 
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Abstract
Preeclampsia is a pregnancy-related syndrome that is one of the frequent reasons of neonatal and maternal deaths and illness throughout the world. Preeclampsia affects roughly 2% to 8% of all pregnancies, resulting in more than 63,000 maternal fatalities per year around the world.
Early detection of preeclampsia would allow for intervention and attentive monitoring, reducing the disorder’s negative implications. The following are some of the preeclampsia complications;
o Fetal growth restriction.
o Preterm birth.
o Placental abruption.
o Disseminated intravascular coagulopathy.
o HELLP syndrome.
o Eclampsia.
o Other organ damage as pulmonary edema, hepatic failure and renal failure.
Although the exact origin of preeclampsia is uncertain, the pathophysiology is assumed to be divided into two stages. The first step occurs with in placental, whereas the second part is marked with an aberrant maternal endothelial reaction that leads to hypertension, protein in urine, as well as edema.
Preeclampsia patients can have higher serum uric acid levels due to DROP in kidney urate output. Endothelial brokenness, oxidative digestion, platelet adhesiveness, and aggregation have all been linked to hyperuricemia caused by oxidative pressure.
Raised serum uric acid is a strong predictor of increased risk of undesirable maternal and neonatal consequences. Calcium has an important role in muscular compression and the regulation of water balance in cells, according to the physiological principle. The adjustment of circulatory strain is triggered by changes in plasma calcium fixation. In preeclamptic women, lowering blood calcium and increasing intracellular calcium can produce an increase in arterial blood pressure.
Patients feel Doppler examinations to be non-invasive and tolerable. Throughout third trimester of gestation, umbilical arterial Doppler examination is utilized to monitor fetal well-being. Umbilical arterial Doppler is a test that can detect placental insufficiency and, as a result, intrauterine growth restriction (IUGR) or preeclampsia. In high-risk obstetric circumstances, umbilical artery Doppler evaluation was found to lower neonatal deaths and illness.
In the present study, we aimed to study the role of maternal serum uric acid and calcium versus Umbilical artery Doppler blood flow in preeclamptic patients at 28-30 weeks of gestation compared to Normotensive pregnant participants at El-Shatby Maternity University Hospital.
This study involved 90 pregnant women who had been admitted to El-Shatby Maternity University Hospital, where they had been divided into two main groups. At 28- 30 weeks of gestation, 45 healthy normotensive pregnant females (control group) and 45 patients with preeclampsia (cases); 20 mild cases and 25 severe cases were compared.
The findings of our study revealed no significant difference in age across study groups; however BMI was significantly greater among severe preeclampsia group.
As regards of the occurrence of previous preeclampsia, there were significant differences among study groups.