الفهرس 
Sickle Cell DiseaseOnly 14 pages are availabe for public view
 |  | from | 131 |  |  |
| | | from | 131 | | |
Abstract
Sickle cell disease is one of the large health problems in many
areas of the world. It is characterized by multisystem complications
that had a marked variability in its severity among patients that may
be linked to nitric oxide. Endothelial nitric oxide synthase variants
have been found to be associated with several vascular disorders as
well as the pathogenesis of sickle cell disease complications.
The aim of this study is to explore the possible association
between the endothelial nitric oxide synthase eNOS (T786C) gene
polymorphisms and disease severity in pediatric patients with SCD.
The study was carried out on 21 children diagnosed as SCD
patients of both sexes, and 21 healthy children of matched age and sex
as a control group, patients were selected from Pediatric Hematology
Oncology Unit, Faculty of Medicine, Menoufia University. Lab tests
were done at clinical pathology department, National Liver Institute,
Menoufia University.
Inclusion criteria:
Children diagnosed with SCD.
Children of both sexes & less than 18 Years old.
Exclusion criteria:
Children with other types of anemia.
Presence of clinical comorbidities.