الفهرس 
Bioresorbable Vascular ScaffoldsOnly 14 pages are availabe for public view
 |  | from | 114 |  |  |
| | | from | 114 | | |
Abstract
This study demonstrated the feasibility and efficacy of PLLA-based bioresorbable scaffolds in variable clinical and lesion related settings. Midterm OCT analysis of Absorb and DESolve devices shows acceptable and comparable late lumen loss and neointimal coverage to current generation DES. However, differences in scaffold mechanical behaviour and neointimal growth were also observed between the two devices despite similar basis composition. The divergence of the observed clinical outcomes between the studied scaffolds reinforces the opinion, that the “failure” seen with current generation Absorb scaffold should not be extrapolated to all available bioresorbable devices. Careful lesion selection, applying BRS specific implantation strategy and routine use of invasive imaging are needed to optimize the outcomes and to deepen our understanding of this technology, its limitations and improvement potentials. Reducing strut thickness while improving scaffold mechanical properties and optimizing its resorbtion/erosion profile are vital issues to be addressed in the next generation of bioresorbable vascular scaffolds. While technological developments are needed in order to fill the gap with current metallic DESs, we believe that BRSs are one of the most relevant innovations in coronary interventions and may eventually lead to long term clinical benefits.