الفهرس 
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Abstract
Introduction : Psoriasis is a common chronic immune-mediated disease that affects 1–3% of the population. Psoriasis is now classified as a systemic immune-mediated inflammatory disease (IMID) of the skin which is mediated mainly by Th1 and Th17 cells with production of large amounts of proinflammatory cytokines (such as TNF-α, IL17, IL22, and adipokines) ( Kim and Kreuger 2015). Some studies reported that alterations in adipokine levels in psoriasis are similar to that found in obesity but independently associated with psoriasis (Kumar et al. 2013). Among all the adipokines Apelin is a newly discovered peptide hormone which has recently been linked to insulin resistance and obesity. The predominant circulating isoforms are apelin-13 and -36 (Lee et al. 2000). The Aim of this study: This study was done to investigate the relationship between apelin 36 and insulin resistance and psoriasis. Materials and methods : This study was conducted on two groups : group A (patient group) : includes 40 patients with chronic plaque psoriasis. And group B (control group): includes 40 non psoriatic healthy volunteers who match the patient group as regard age, sex, and body mass index (BMI). Results: The current study revealed that: serum apelin-36 showed significant negative correlation with HOMA-IR in the studied psoriatic patients. These data may indicate that measurement of serum apelin in non-obese psoriasis patients could predict incipient diabetes in those patients with low levels. As a result, diabetes and its complications can be prevented by early detection of pre-diabetic cases in psoriasis patients. These results go in hand with Ma et al. (2014). who found that, the apelin concentration could predict incipient diabetes (the sensitivity was 63.2% and specificity was 58.9%). Conclusion: psoriasis is associated with lower levels of apelin 36 in non-obese patients which is negatively correlated with psoriasis severity as measured by PASI score. Like other adipokines, abnormal apelin level in psoriasis may reflect the effect of chronic systemic inflammation in psoriasis which induce dysfunction of adipose tissues even in non-obese subjects. Also, a state of insulin resistance was found even in patients with mild to moderate psoriasis. And, the propensity of psoriatic population to a prediabetic condition was confirmed even in mild disease. The small sample size is the main limitation of our study.