الفهرس 
Applied Anatomy of Anal Canal and HemorrhoidsOnly 14 pages are availabe for public view
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Abstract
Background: STEMI is the most acute manifestation of CAD, with substantial morbidity and mortality, early reperfusion (re-establishing the blood flow in the occluded artery) is the most effective way to preserve the viability of the ischaemic myocardium and limit infarct size so early diagnosis of STEMI is crucial to initiate appropriate treatment and should ideally be made within 10 minutes of first medical contact.
Objective: To demonstrate the possibility of mi-RNA499 to become novel biomarker for the diagnosis of STEMI in comparison with cardiac troponin.
Subjects and Methods: The current work was a prospective study conducted on a total number of 50 cases to detect circulating miR-499 and their association with Acute STEMI in comparison to cardiac troponin. This study was conducted during the period from July 2020 to January 2021 on 50 Egyptian adult patients who presented with STEMI in the emergency department of Menufia University Hospital divided in two groups: group 1: 25 patient who presented within the first 4 hour of STEMI diagnosis. group 2: 25 Egyptian adult patients who presented after 4 hour of STEMI diagnosis.
Results: In group 1(early presentation), the majority was males (84%) with mean age 53.24 years. In group 2 (late presentation), the majority was male (88%) with mean age 54.20 years. As there was no statistically significant difference between the 2 studied groups as regard age, sex (p=0.750 & 0.684 respectively). There was no statistically significant difference between the 2 studied groups as regard risk factors, ECG finding (p=0.756) and ejection fraction with mean EF 61.12 &58.8 respectively (p=0.188). In early group the median value of troponin, CKMB, microRNA-499 was (0.33, 25, 1.5 respectively), while in late group the median value of troponin, CKMB, microRNA-499 was (6.5, 123.1, 9.5 respectively).
Conclusion: There was no statistically significant difference between the 2 studied groups as regard risk factors, ECG finding (p=0.756) and ejection fraction with mean EF 61.12 &58.8 respectively (p=0.188).