الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Syncope is a common clinical problem challenging both cardiologists and general practitioners Syncope is typically defined as a self-terminating transient loss of consciousness (TLOC) and postural tone caused mainly by global cerebral hypo-perfusion. It is essential to discriminate syncope from other disorders that are accompanied by TLOC such as seizure, hypoglycemia, anemia or hypovolemia. Biomarkers pose an opportunity to improve diagnosis, prognostication and monitoring for the syncope patients. In our study, we selected a number of circulating micro-RNAs and vasoactive amines to be evaluated in attempts to identify possible biomarkers for syncope. To the best of our knowledge, this is the first study to assess the changes in miRNAs in syncope patients.The study protocol was approved by Alhyatt heart and vascular center ethics committee and informed consent was obtained. Thirty eight patients were recruited and classified into two groups, nineteen patients who experienced one or more previous episodes of syncope during the past six months were recruited into group A and nineteen healthy individuals with no history of syncope were recruited into group B. All recruited patients were asked for a detailed medical history and underwent a cardiovascular examination followed by head up tilt table testing (HUTT), which was performed according to the New Castle protocol. Exclusion criteria included epileptic patients, age <18 years and patients currently taking any antidepressants or antianxiety medications. Three blood samples were withdrawn, 5ml from each subject , first one at baseline, second during syncopal attack and third one after 30 minutes from the end of the test.