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Dedication
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List of contents
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List of abbreviations
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List of tables
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List of figures
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Introduction
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Aim of the work
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Review of Literature
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Mucosal-associated invariant T (MAIT) cells
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Antigens detected by MAIT cells
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Tools for studying MAIT cells
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MAIT cell development
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MAIT cell activation and effector function
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MAIT cell subsets
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Systemic lupus erthymatosus (SLE)
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Etiology/pathophysiology
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Diagnosis of SLE
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Immunopathogenesis in SLE
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Environmental risk factors
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Genes and gene expression
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Apoptosis and nucleic acid sensors
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Soluble mediators
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Some cell types involved in SLE
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MAIT cells in SLE
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Patients and methods
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Subjects
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Materials and Methods
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Results
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Demographic, clinical, and laboratory characteristics of patients with SLE
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Levels of mucosal-associated invariant T (MAIT) cells, MAIT cell subsets, and HLA-DR+ MAIT cells in SLE patients and healthy controls
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Comparison of interferon gamma-induced protein 10 (IP-10) between patients and controls and its relation with disease activity
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Levels of MAIT cells and HLA-DR+ MAIT cells in SLE patients according to the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)
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Levels of MAIT cells and HLA-DR+ MAIT cells in SLE patients in relation to lupus nephritis
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Correlations of MAIT cells and HLA-DR+ MAIT cells with the different clinical and laboratory findings in SLE patients
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Correlations among MAIT cells and HLA-DR+ MAIT cells
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Discussion
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Summary
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Conclusion
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Recommendations
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References
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Arabic Summary
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الملخص العربي