الفهرس 
Polycystic ovarian syndrome (PCOS)Only 14 pages are availabe for public view
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Abstract
olycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting reproductive aged women.
PCOS is a complex disease with reproductive, metabolic and psychological features. Infertility is a prevalent presenting feature of PCOS with " ~ "75% of these women suffering infertility due to anovulation, making PCOS by far the most common cause of anovulatory infertility.
The diagnosis of PCOS in women is usually done according to the ESRHE/ASRM criteria known as Rotterdam criteria, which is based on having at least two of three characteristics of oligo-ovulation/anovulation, hyperandrogenism and polycyclic ovaries using ultrasonographic images.
Periostin is a 90-kilodalton secretory protein originally identified as an osteoblast-specific factor that is preferentially expressed in the periosteum and functions as a cell adhesion molecule.
The aim of the present study was to to assess the periostin levels in patients with polycystic ovary syndrome to measure the ability of this factor for diagnosis of PCOS.
The present study was conducted on 40 subjects suspected to have PCO according to the ESRHE/ASRM criteria known as Rotterdam criteria, 20 PCO patients and 20 non PCO patients not fulfilling Rotterdam criteria.
Blood samples were taken for the detection of Serum periostin levels by using Enzyme Linked Immune Sorbent Assay (ELISA) technique.
This study suggests more investigation on larger number of patients to obtain better knowledge of the association between polycystic ovary syndrome and elevated serum periostin levels and the ability of serum periostin levels to diagnose polycystic ovary syndrome.
The comparative laboratory parameters of the studied women with PCOS and without PCOS show that there was no statistical significant difference between the two studied groups regarding cholesterol, HDL-C, LDL-C, FSH, LH, estradiol, blood glucose levels at fasting and all post prandial periods (P value > 0. 05 for all). While the PCO patients have higher uric acid, TG, Periostin and WHR levels compared to the control groups (p value 0.009, 0.01, <0.001, 0.008 respectively).
This results supports the growing evidence polycystic ovary syndrome is associated with elevated serum periostin levels. It suggests periostin as a potential biomarker in the management of PCOS.