الفهرس 
Acne VulgarisOnly 14 pages are availabe for public view
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Abstract
Acne vulgaris (AV) is a chronic inflammatory long term skin disease of the pilosebaceous unit. There are numerous factors in the etio-pathogenesis of AV. The main factors are inflammation, abnormal keratinization, microbial flora changes, and increased sebum production. The sequence in which these events occur is still not certain, but recently, inflammation has been suggested as the initial factor. The mechanisms behind the beginning and maintenance of the inflammatory response are not fully known, but cutibacterium acnes plays an important role in these mechanisms. Reports vary, but incidence rates suggest that acne is more frequent and severe during adolescence (70% to 87% of the adolescent population), although onset may be delayed until the age of 30 or 40. The frequency of acne in the adolescent population increases with age and frequently, but not always, resolves in adulthood. Calprotectin is the heterodimer form of S100A8 and S100A9, which are members of the S100 protein family and which play a role in various inflammatory process. Calprotectin can be detected in many body fluids, including feces, serum, saliva, and synovial fluid. Serum calprotectin levels increase in various cancers, inflammatory diseases and autoimmune diseases. In addition, calprotectin has been found to be more accurate than other laboratory markers of inflammation, such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). However, to our knowledge, only two researches have evaluated the role of calprotectin in AV patients. In this study, we aimed to study the calprotectin levels in patients with Acne Vulgaris and correlate these levels to the activity and severity of the disease.
In this study, 80 subject (40 patients with acne vulgaris and 40 healthy, age and gender matched acted as a control group) after assessment of their cases using History of the case, Dermatologic Life Quality Index (DLQI) questionnaire, applying general examination and dermatological examination to ensure complying with research agreed criteria. The selected patients were employed to assess the level of calprotectin as inflammatory marker in Acne Vulgaris and correlate its levels to the activity and severity of the disease.