الفهرس 
Structure of the SkinOnly 14 pages are availabe for public view
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Abstract
Psoriasis is a common autoimmune inflammatory skin disease, with no clear cause, treated with topical agents and phototherapy to conventional immunosuppressant drugs and biologic agents. Stem cell therapy has showed significant interest in regenerative medicine. The aim of this study was to use mesenchymal stem cell (MSC) therapy compared to the topical application of the standard conventional corticosteroid cream.
Material &methods: 40 male adult albino rats were used, divided into 4 groups, 10 rats each. group I (control), group II (Psoriasis-like lesions induced by usage of Aldara cream), group III (treated with Betamethasone) and group IV (treated with mesenchymal stem cells). Specimens were stained with Hematoxylin & Eosin, Masson’s trichrome, immune-histochemical technique for CD4, CD8 and CD31. Ultra-sections were prepared for transmission electron microscope examination.
Results: MSCs demonstrated efficacy in reduction of disease severity in the form of uniform epidermal thickness covered by a very thin keratin layer. Normally- arranged layers of epidermal layers, with a clear border demarcation was seen between the epidermis and the dermis with apparently intact basement membrane. TEM showed absence of gaps between the tightly connected cells of the basal layer and the resting basement membrane.
Conclusion: application of MSCs raises hope for developing a new, safe and effective therapy for psoriatic patients, avoiding the side effects of betamethasone.