الفهرس 
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Abstract
Acinetobacter Baumannii (A. Baumannii) Is An Opportunistic Microorganism Commonly Found In Intensive Care Units (Icus), And It Is Responsible For A Broad Span Of Hospital-Acquired Infections. Persistence Of Nosocomial Infection Caused By Multi-Drug Resistant (MDR) A. Baumannii Is An Alarming Health Care Issue In Egypt, And At Present, Colistin Remains The Treatment Of Choice For The Management Of MDR A. Baumannii Infections. A. Baumannii Possesses Great Capacity To Develop And Acquire Resistance To A Broad Range Of Antibiotics. The Acquisition And Dissemination Of Antibiotic-Resistant Determinants In A. Baumannii Strains Are Mediated By Integrons, Especially Class I Integrons. This Study Focuses On The characterization Of Some Genetic Mechanisms Underlying The Multidrug-Resistant Phenotypes Of A. Baumannii Isolates In Egypt. Forty-Eight A. Baumannii Specimens Were Isolated from Different Hospitalized Patients; Least Resistance Was Observed Against Amikacin And Tigecycline, With 60% And 58.5% Of The Isolates Resistant, Respectively, Whereas 62.5% Of The Isolates Were Resistant To Imipenem And Meropenem. The Highest Sensitivity Was Found For Colistin. Genetic Analysis Revealed That Blaoxa-51-Like Gene Was Detected In All Isolates; Blaoxa-23-Like Gene Was Detected In 80% Of The Isolates, While Blaoxa-24-Like Gene And Blaoxs-58-Like Gene Were Not Detected In Any Isolate. Finally, PCR Analysis Revealed That 6.6% Of Isolates Carried The Class I Integron Gene.