الفهرس 
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Abstract
Periodontitis is a global disease affects abroad age range. It can be caused by the interaction between periodontal pathogens and host immune response. Cytokines have a key role in the pathogenesis of periodontal diseases especially matrix metalloproteinases-8 (MMP-8) is believed to be the most important enzyme in the connective tissue destruction. Assessing levels of MMP-8 in GCF is a strongly recommended for diagnosis and follow-up the course of periodontal treatment.
The present study conducted to investigate the levels of MMP-8 in GCF after intrapocket application of Cymbopogon citratus oil gel as an adjunct to non-surgical treatment in moderate periodontitis patients. This study included forty subjects. All subjects were belonged to patients having moderate periodontitis (stage II), CAL 3-4mm, with an age ranging from 25 to 45 years old, with no history of previous periodontal therapy or taken any antibiotic therapy for the past six months. 40 patients were divided equally into two groups. All subjects were evaluated clinically and radiographically at the first visit for diagnosis and selection of the patients. After selection subjects, GCF samples were collected after dryness area, PI, BOP, PPD and CAL were assessed, and SRP was performed for each subject. Gel (lemongrass oil/ or placebo) was administered intrapocket. Patients were recalled for follow-up after a week to collect GCF samples, and after twelve weeks to reassess PI, BOP, PPD, CAL, and GCF collection. The GCF samples were sent to lab and analysed by ELISA-kit.
The results of this study showed a statistically significant decrease in PI, BOP, CAL, and MMP-8 at the end of study in lemongrass oil gel group (P value < 0.001). There was statistically insignificant difference in PPD (P= 0.147) as compared two groups at end of the study but was decreased significantly through each group individually and was more in lemongrass oil gel/SRP group than placebo/SRP group.