الفهرس 
Epidemiology:
Sepsis-induced disseminated intravascular coagulation (DIC)Only 14 pages are availabe for public view
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Abstract
The present study was designed to estimate the circulating sRAGE levels in patients with sepsis and study the correlation between its level and the severity of the disease. It was performed on
the in-patients admitted at the Surgical ICU Department, Faculty of
Medicine, Tanta University.
It included 30 septic patients (group I) which were divided
into 3 subgroups according to definition of sepsis by using
APACHE II and SOFA scores:
(Ia) sepsis: 11 patients.
(Ib) severe sepsis: 14 patients.
(Ic) septic shock: 5 patients.
Additionally, 30 healthy subjects were included as a control
group (group II).
All participants of the study were subjected to the following:
1) Full history taking and history of any comorbidity if present.
2) Complete clinical examination.
3) Recording of the site and severity of sepsis (for patients
only).
At the time of patient enrollment, definition of severity of
illness was performed through APACHE II and SOFA score. Also,
ISTH DIC scoring system for diagnosis of overt DIC was used.
4) Routine laboratory investigations such as CBC, liver
function tests, kidney function tests and CRP were
performed.
5) Assessment of circulating (sRAGE) by ELISA technique.
Results of the present work revealed that sRAGE ranged from (611-2238, 645-2873, 1875-3140 and 357-932) pg/ml with a mean
value of (1135+467, 1580+568, 2515+514 and 712.5±137.2) in
sepsis (Ia), severe sepsis (Ib), septic shock (Ic) and control group
(II), respectively. There were statistically significant differences in
sRAGE levels between patients and control groups (P-value
<0.001).