الفهرس 
PsoriasisOnly 14 pages are availabe for public view
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Abstract
Psoriasis is a common chronic autoimmune and inflammatory skin disease in which both genetic and environmental factors have a critical role. The most characteristic lesion is red, scaly sharply demarcated, indurated plaques over extensor surfaces and scalp. It affects 2.7% of the world’s population.
Cysteine-rich angiogenic inducer 61 (CYR61) or CCN family is a secreted, extracellular matrix (ECM)-associated signaling protein of the CCN family (CCN intercellular signaling protein). CYR61 is capable of regulating a broad range of cellular activities, including cell adhesion, migration, proliferation, differentiation, apoptosis, and senescence through interaction with cell surface integrin receptors and heparan sulfate proteoglycans. During embryonic development, CYR61 is critical for cardiac septal morphogenesis, blood vessel formation in placenta, and vascular integrity. In adulthood CYR61 plays important roles in inflammation and tissue repair, and is associated with diseases related to chronic inflammation, including rheumatoid arthritis, atherosclerosis, ndiabetes-related nephropathy and retinopathy, and many different forms of cancers.
The aim of this study was to evaluate immunohistochemical expression of CYR61 in involved skin in patients having psoriasis vulgaris to clarify its possible role in the pathogenesis of this disease.
The aim of this study was to study possible role of CYR61 in psoriasis vulgaris by immunohistochmeical study of its expression in skin biopsies of psoriatic patients and to correlate its expression with the available clinico-pathological data. The present study included 50 subjects; 30 patients with psoriasis vulgaris and 20 age and gender matched healthy subjects as a control group.
Inclusion criteria included cases newly diagnosed with psoriasis vulgaris irrespective of age and gender. Exclusion criteria included patients with any dermatological disease other than psoriasis, patients with any systemic or autoimmune diseases.
Patients and controls were subjected to complete history taking, complete general and dermatological examination, including assessment of PASI score to evaluate severity of psoriasis in the patient group. Punch skin biopsies from psoriatic skin including lesional and perilesional skin, and punch skin biopsies also taken from control subjects. from these biopsies, sections were stained by H&E and CYR61 stains. In the current study, there was a significant stepwise overexpression of CYR61 in epidermal keratinocytes from controls (63 ±30.5) to perilesional (127 ± 48.1) and lesional (166.7 ±69.1) skin (P < 0.001). There was a significant overexpression of CYR61 expression in dermal inflammatory cells of lesional psoriatic skin (145 ± 75.9) when compared to control skin (84.5 ± 42.5). Both lesional and perilesional dermal skin showed significantly higher H- score mean values when compared to controls (P =0.00 and P =0.002) respectively. There was significant positive correlation between CYR61 H- score values in lesional epidermis and PASI score (r = 0.63; P =0.00). Also, there was significant positive correlation between H- score of CYR61 in lesional dermis and PASI score (r = 0.55; p =0.001).