الفهرس 
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Abstract
Objective:
This study was premeditated to elaborate an optimized fluticasone propionate (FP)–loaded solid lipid nanoparticles (SLNs).
Significance:
Enhance FP effectiveness for topical inflammatory remediation.
Methods:
The influences of drug amount, lipid, and surfactant ratios, on particle size (Y1), zeta potential (Y2), along with the percentages of entrapment efficacy (Y3), initial release (Y4), and cumulative release (Y5) were studied and optimized for the prediction of the optimized formula utilizing Box-Behnken design. Differential scanning calorimetry, electron and light microscopical examination, along with an In-vivo evaluation via carrageenan-induced rat paw edema in comparison with Cutivate®, were conducted for the optimized SLNs.
Results:
248.3 nm, -32.4 mV, 77.85 %, 12.6 %, and 92.5 % were the detected responses of the optimized SLNs for Y1, Y2, Y3, Y4, and Y5, respectively. The spherical assembly of the optimized FP–loaded SLNs with good stability physiognomies were evidenced. Moreover, a distinguished anti-inflammatory activity was