الفهرس 
Aim of the workOnly 14 pages are availabe for public view
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Abstract
Since December 2019, several Wuhan city hospitals (Hubei Province,
China) had detected unidentified pneumonia when it was recognized as a
novel coronavirus (nCoV). The virus soon spread to other countries and
regions within two months (Singhal 2020) . The outbreak has already spread
to 220 countries worldwide, infecting more than 180 million individuals and
triggering more than 3.9 million fatalities (WHO 2021) . Egypt announced the
detection of the first case of corona virus disease 2019 (COVID-19) on the
14 th of February 2020 (WHO 2020) .
CoV is a wide family of viruses that cause diseases ranging from mild
colds to more severe diseases, such as Middle East Respiratory Syndrome
(MERS) and Severe Acute Respiratory Syndrome (SARS). On 11 th February
2020, the International Committee for Virus Taxonomy released a statement
confirming the formal name for the novel virus: " SARS-CoV2" (Lescure et
al., 2020) .
The diagnosis relies on estimating the likelihood of contact with an
infected patient, the clinical signs & symptoms and detecting the viral
ribonucleic acid (RNA) by polymerase chain reaction (PCR) in respiratory
samples (Singhal 2020) .
The full clinical presentation of COVID-19 is still not understood, but
among the most common presentations are; cough, fever, dyspnea, anosmia
and pneumonia. Currently, there is no effective antiviral therapy for treating
SARS-CoV2 infection (Raman et al., 2021) . So, early identification of the
severity of the disease is very important to enable intervention to reduce the
mortality risk and predict prognosis (Xu et al., 2020b) .
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The inflammatory cytokine storm has been recognized as the primary
cause of death in patients with COVID-19 (Chen et al., 2020a) , which is
defined by the excessive and uncontrolled release of pro-inflammatory
cytokines (PICs), as has been reported in other infections caused by
pathogenic CoVs (Qin et al., 2020) . For instance, inflammatory cytokines
released by macrophages (interleukin 6 (IL-6), interleukin10 (IL-10) and
tumor necrosis factor α (TNF-α)) increase in patients with severe COVID-19
disease, resulting in damage to the lungs and other organs (Chen et al.,
2020a) . Consequently, measurements of plasma inflammatory markers such
as Ferritin, Lactate dehydrogenase (LDH) and C-reactive protein (CRP) may
predict the disease's seriousness (Zhao et al., 2020a) .
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Aim of the Work
Collection and analysis of the hematological characteristics of COVID-
19 patients admitted to Fayoum University Hospital (FUH) between April
and July 2020.