الفهرس 
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Abstract
Vitamin D deficiency and type 2 diabetes mellitus (T2DM) are two interrelated and most basic medical issues in the world. Such interrelationships involved complex inheritance pattern. The polymorphisms of different genes including vitamin D receptor (VDR) may influence hereditary susceptibility of T2DM by making defect in beta pancreatic cells or insulin resistance. Many studies applied on different population proved that, there is important relation between diabetic complications incidence and different types of vitamin D receptor gene polymorphisms and vitamin D deficiency. This study examined the correlation between Vitamin D deficiency and two vitamin D receptor polymorphisms FokI (VDR 2228570 C >T) and BsmI (VDR 1544410 A >G) and the frequency of type 2 diabetes mellitus complications among Egyptian patients.
100 Egyptians involved in this study classified as 80 patients diagnosed as diabetic patients with different complications, and 20 normal people as control. All of these subjects had specific criteria and having blood examination for biochemical parameters including (Vit D - HbA1c - CBC - HCV abs - creatinine – UREA - Micro-albuminuria – SGPT- SGOT - albumin - INR – Calcium(total) - Phosphorous - lipid profile (cholesterol, TG, HDL. LDL) and genotyping analysis including (DNA extraction – two VDR SNPs, namely FokI (VDR 2228570 C > T) and BsmI (VDR 1544410 A > G) were genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR– RFLP)).
The results showed that the deficiency of vitamin D was more prevalent in diabetic cases than in control cases and there was significant difference between diabetic patients and control in genotyping of FokI (VDR 2228570 C>T) unlike BsmI (VDR 1544410 A > G).
The finding revealed that vitamin D deficiency related to T2DM among Egyptian patients. And there was a genetic variation in the VDR gene related to diabetic mellitus, FokI SNPs were associated with susceptibility to T2DM complications in Egyptian patients.