الفهرس 
DEPDC5 GeneOnly 14 pages are availabe for public view
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Abstract
HCC represents an international public health concern as one of the most common and deadly cancers worldwide. It is the third most common cause of cancer-related death worldwide. In Egypt, HCC is the second most common cancer in men and the 6th most common cancers in women.
In most cases, HCC develops within an established background of chronic liver disease (70–90% of all patients). The worldwide heterogeneous incidence reflects variations in the main risk factors which include cirrhosis, viral hepatitis (HBV and HCV), aflatoxin, exposure to pesticide and genetic host factors.
DEPDC5 is a human protein of poorly understood function. An intronic SNP (rs1012068) in DEPDC5 gene has been associated with a 2-fold hepatocellular carcinoma-risk increase in some ethnic groups.
Moreover, heterozygous mutation in the DEPDC5 gene is a common genetic factor for epileptic syndromes, including familial focal epilepsy with variable foci-1 (FFEVF1).
The aim is to study the association of DEPDC5 gene polymorphism (rs1012068) and evaluate its allele distribution in hepatocellular carcinoma in chronic hepatitis C Virus Egyptian patients.
A total of 100 subjects involving 75 patients and 25 healthy controls with matched age and sex were the subjects of this study. They were randomly selected from Menoufia University Hospitals in the period between February 2019 and February 2020. The studied subjects were divided into 4 groups: group І: 25 apparently healthy individuals as controls, group П: 25 chronic hepatitis C virus patients, group Ш: 25 HCV induced liver cirrhosis patients and group IV: 25 HCV induced hepatocellular carcinoma (HCC) patients.
This study showed that INR, AST, ALT, ALP, GGT, total bilirubin, direct bilirubin, and AFP were significantly higher in HCC patients compared to control group. On the other hand, Hb, platelets, total protein and albumin were significantly lower in HCC patients compared to controls.
Considering DEPDC5 gene polymorphism There were no statistically significant differences in DEPDC5 rs1012068 allele frequencies between the patient’s groups and control group or between patient’s groups each other.