الفهرس | Only 14 pages are availabe for public view |
Abstract Novel three-dimensional biodegradable porous hybrid polymer- hydroxyapatite nanocomposite bone scaffolds have been developed using acacia gum and gelatin as base polymer matrix and magnesium doped nano hydroxyapatite as cementing materials using gamma irradiation facility for cro ss linking and sterilization process. Hydroxyapatite and Magnesium doped Hydroxyapatite nanoparticles were synthesized using wet chemical method. X -ray diffraction studies confirmed the HAp nano scale size. The energy dispersive X-ray analysis revealed the presence of ea, P and 0 in the prepared n-HAp in addition to Mg in tbe doped HAp samples. The developed scaffolds show adequate mechanical properties and porosity degree as well as a promising antibacterial activity against Staphylococcus aureus and Escherichia coli. In vitro cytotoxicity and blood compatibility evaluation confirm their biocompatibility. Ketoprofen loaded scaffolds were able to deliver the loaded drug in a sustainable manner. Development of controlled drug release earners with gastroretentive ability is one of the most feasible approaches to improve the bioavailability and efficiency of medical treatment of Helicobacter pylori induced peptic ulcer. Modification of alginate with N, N-Dimethylaminoethyl Methacrylate was occurred via graft copolymerization technique using y-irradiation. |