الفهرس 
Aim of the workOnly 14 pages are availabe for public view
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Abstract
Intraventricular hemorrhage (IVH) is a major cause of morbidity and mortality in preterm neonates. Elucidation of the mechanisms underlying IVH and/or development of disease biomarker is essential.
Alteration of amino acids metabolism is due to decrease energy production and neurotransmitter synthesis, this alteration caused by brain injury and asphyxia.
Carnitine has an important role in facilitating medium- and long-chain fatty acid transport from the cytosol into mitochondria for β-oxidation and energy generation. In addition, carnitine stimulates pyruvate dehydrogenase complex activity and the Krebs cycle, increasing branched-chain amino acids oxidation in muscles.
In a recent study, evaluating the initial metabolic profile in infants born at the limits of viability,some Acylcarnitines were found to be particularly important to survival in infants with IVH, and possibly indicators of IVH severity.
Aim of study is study the predictive ability of the serum Acylcarnitines and serum amino acids level as potential biomarkers for early detection of intra ventricular hemorrhage in premature neonates.
The study was performed on 40 preterm infants. They divided into two groups; IVH group (20 preterm infants, 4 females (20%), 16 males (80%), with GA less than 37 weeks (Mean± SD 32.05 ± 2.16) and weighs less than 2.5 kg (Mean± SD 1571.50 ± 361.68)). Control group (20 preterm infants, 4 females (20%), 16 males (80%), with GA less than 37 weeks (Mean± SD 32.75 ± 2.07) and weighs less than 2.5 kg (Mean± SD 2195.0 ± 270.43)). Data was collected, tabulated and statistically analyzed using descriptive statistics and analytic statistics, it showed that
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study groups differed significantly in serum amino acids and Acylcarnitines profiles.
All groups were subjected to full history taking, thorough clinical examination including assessment of gestational age,Apgar score and laboratory investigations included CBC, CRP, liver and kidney functions, Na, K, Ca, lactate, ABG, PT, PTT, and determination of amino acids, carnitine and Acylcarnitines levels.
The resutls of the present study revealed that:
Our results showed that:
There was highly significant decrease in Weight in IVH preterm group compared to control preterm group, but there was no statistical significant in Gender, Gestational age, Mother age and Mode of delivery in IVH group regards control group.
There was highly significant increase in Mechanical ventilation and highly significant decrease in Apgar score in IVH preterm group compared to control group, and there was significant increase in Bicarbonate administration and Shock therapy in IVH preterm group compared to control group, but there was no statistical significant in Tracheal suction in IVH group as regards control group.
There was no statistical significant in Hypertension, DM, Cardiac disease, PROM and Maternal Drugs in IVH group compared to control group.
There was highly significant decrease in Diastolic BP in IVH group compared to control group, and there was significant decrease in Temperature and Systolic BP in IVH group compared to control group, and there was significant increase in Convulsion in IVH
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group as regards control group but there was no statistical significant in HR and RR in IVH group as regards control group.
There was significant decrease in PH and HCO3 in IVH group compared to control group, and there was significant increase in Urea in IVH group compare to control group,but there was no statistical significant in HB, PLT, HCT, WBCS, Blood culture, CRP, PCO2, SGOT, SGPT, PT, PTT, Creatinine, NA, K, Ca, Blood glucose and Lactate in IVH group as regards control group.
There was significant increase in Alanine, Asparagine, Glutamine and Ornithine in IVH group compared to control group, but there was no statistical significant in Arginine, Glysine, Valine, Proline, Leu:Ala and Leu:Phe in IVH group as regards control group.
There was significant increase in C3:C2 and C6 carnitines in IVH group compared with control group, but there was no statistical significant in C0, C10, C16, C2, C3, C4, C5, C4OH, C12, C14, C8:1 carnitines in IVH group compared to control Group.
There was significant increase in Alanine, Asparagine, Glutamine, Glysine, Valine, Proline and Ornithine in IVH group compared to control group, but there was no statistical significant in Arginine, Leu:Ala and Leu:Phe in IVH group as regards control group.
There was significant increase in C3:C2 and C6 carnitines in IVH group compared with control group, and there was significant decrease in C8:1 in IVH group regards control group but there was no statistical significant in C0, C10, C16, C2, C3, C4, C5, C4OH, C12 and C14 carnitines in IVH group compared to control Group.
There was significant increase in Arginine, Glutamine and Lue:Phe in IVH group at day1 compared to IVH group at day3, but there was
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no statistical significant in Alanine, Asparagine, Glysine, Valine, Proline, Ornithine and Lue:Ala in IVH group at day1 as regards IVH group at day3.
There was no statistical significant in C0, C10, C16, C2, C3, C3:C2, C4, C5, C4OH, C12, C14, C8:1 and C6 carnitines level in IVH group at day1 compared to IVH group at day3.
There was highly statistical significant decrease in the number of survived of IVH group compared to Control group.
There was no Correlation in significant laboratory data at the 1st three days compared to significant amino acids and Acylcarnitines at day 1 in the IVH group.
There was no Correlation in significant clinical data compared to significant amino acids and Acylcarnitines at day 1 in the IVH group.